Newcomer joints old familiar faces.

نویسنده

  • Hisashi Kai
چکیده

akayasu arteritis (TA) is a chronic vasculitis of unknown etiology that involves the aorta and its main branches, such as the innominate, carotid, subclavian, vertebral, and renal arteries, as well as the pulmonary and coronary arteries.1 This disease is more common in young females in Asia, Middle East, and Middle and South America than in Europe and North America. TA has 2 stages: an acute, “prepulseless” phase characterized by non-specific inflammation of the large vessels, followed by a chronic, “pulseless” phase with thickening of the whole vascular wall and susequent luminal narrowing.2 The histological feature of acute-phase TA is a panarteritis extending from the adventitia to the media: the adventitia shows massive infiltration of T cells (CD4+ T cells, CD8+ T cells, γδ T cells, and natural killer cells), neutrophils, macrophages, and dendritic cells. The media is characterized by infiltration of T cells and giant cells and rich neovascularization. In the chronic phase, the thickening of the entire vascular wall is accompanied by adventitial fibrosis, medial fragmentation (because of the destruction of elastic fibers), and intimal thickening associated with proliferation of smooth muscle cells and myofibroblasts and deposition of the extracellular matrix, which leads to luminal narrowing and vascular occlusion.

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عنوان ژورنال:
  • Circulation journal : official journal of the Japanese Circulation Society

دوره 76 7  شماره 

صفحات  -

تاریخ انتشار 2012